With every cough or sniffle, you may wonder if it’s asthma or allergies, the flu, respiratory syncytial [sin-SISH-uhl] virus (RSV), the common cold, or even COVID-19. But how can you tell the difference?

The Asthma and Allergy Foundation of America (AAFA) created a respiratory symptoms chart to help you recognize the similarities and differences between these conditions.

Click to see larger image (English)

Click to see larger image (Spanish)

Asthma Symptoms

Asthma is a chronic disease that causes your airways to be inflamed. The best way to manage it is to take your asthma medicines, avoid your triggers, and treat asthma symptoms as soon as they occur.

Common symptoms of asthma include:

• Shortness of breath
• Cough
• Chest tightness or pain
• Wheeze (a whistling sound when you breathe)
• Waking at night due to asthma symptoms
• A drop in your peak flow meter reading (if you use one)
  
  

Symptoms can come on gradually, or they can come on suddenly.

What to Do If You Have Asthma Symptoms

At the first sign of asthma symptoms, take your quick-relief (sometimes called “rescue”) medicine. Follow the Yellow/Caution Zone on your Asthma Action Plan. The earlier you treat asthma symptoms, the better your chances are of not having an asthma emergency.

Asthma can be life-threatening, so it’s important to know the signs of an asthma emergency and to keep your quick-relief inhaler with you at all times.

Red/Danger Zone symptoms are a medical emergency. Take your quick-relief medicines right away as directed on your Asthma Action Plan and then get immediate medical attention. Call 911 or go directly to the emergency room if you have these asthma symptoms:

• Asthma is getting worse quickly
• Asthma quick-relief medicines are not helping
• Chest tightness or pain
• Severe shortness of breath
• Breathing is faster or slower than normal
• Breathing may be hard or shallow
• Trouble walking or talking due to shortness of breath
• Chest retractions (skin sucks in between or around the neck, chest plate, and/or rib bones when inhaling; this is rare in adults)
• Ribs or stomach moving in and out deeply and rapidly
• Expanded chest that does not deflate when you exhale
• Shoulders hunched over
• Cyanosis, a tissue color change on mucus membranes (tongue, lips, and around the eyes) and fingertips or nail beds – the color appears grayish or whitish on darker skin tones and bluish on lighter skin tones
  
  

COVID-19 Symptoms

COVID-19 is caused by the SARS-CoV-2 virus. According to the Centers for Disease Control and Prevention (CDC), COVID-19 symptoms can include:

• Fever
• Chills
• Cough
• Shortness of breath or trouble breathing
• Feeling tired and weak – more than usual
• Muscle or body aches
• Headache
• New loss of taste or smell
• Sore throat
• Stuffy or runny nose
• Diarrhea
• Nausea or vomiting
  
  

This list may not include all of the symptoms. Symptoms may appear 2 to 14 days after coming in contact with the virus. If you have any symptoms that are severe or concerning, call your doctor.

If you have these severe symptoms, call 911 or go to the emergency room right away:

• Trouble breathing or shortness of breath
• Pain or pressure in the chest that doesn’t go away
• New and sudden confusion
• Can’t wake up or stay awake
• Cyanosis which is tissue color changes on mucus membranes (like tongue, lips, and around the eyes) and fingertips or nail beds – the color appears grayish or whitish on darker skin tones and bluish on lighter skin tones
  
  

People ages 6 months and older can get a COVID-19 vaccine.

What to Do If You Have COVID-19 Symptoms

If you have any of the symptoms above or if you have been exposed to someone who has COVID-19, get tested. If you test positive, contact your doctor right away. They may want you to take an antiviral medicine and or additional medicines to support your symptoms.

Also wash your hands often, wear a mask, and stay home if you are sick. Pay attention to your symptoms, and if they get worse, call your doctor and get emergency care right away. Get plenty of rest and continue to take your asthma medicines as prescribed by your health care provider.

Flu (Influenza) Symptoms

The flu is a contagious respiratory illness caused by influenza viruses. Symptoms can start suddenly and can cause mild to severe illness. It can also cause death in severe cases. Common flu symptoms include:

• Fever (often very high, 101°F or above)
• Headache
• Extreme tiredness
• Chills
• Constant cough
• Sore throat
• Runny or stuffy nose
• Body aches in bones and/or muscles
• Diarrhea and vomiting (more common in children)
  
  

Thankfully, a flu vaccine is available. To reduce your chances of getting and spreading the flu, get the flu vaccine every year. The CDC recommends that people ages 6 months and older get the flu vaccine. Even if you catch a strain of flu that isn’t covered by the current year’s vaccine, getting vaccinated can make your illness less severe and lower your chance of being hospitalized.

People with asthma, as well as senior adults and people with other pre-existing conditions, are at high risk of complications from the flu.

It is important to get the flu vaccine every year. It can reduce your chances of having complications (serious health problems).

What to Do If You Have Flu Symptoms

If you have flu symptoms or are exposed to someone with the flu, contact your doctor right away. There are antiviral treatments for the flu that can lessen symptoms and may shorten the time you are sick. But you have to take them within 1 to 2 days of getting sick.

If you start having flu symptoms and have trouble breathing, follow your Asthma Action Plan and contact your doctor right away.

Respiratory Syncytial Virus (RSV)

RSV is a virus that affects your lungs. It is a common virus with cold-like symptoms that can affect people of all ages. RSV is the most common cause of pneumonia and airway inflammation in children in the United States younger than 1 year of age.

Most people have mild symptoms and recover from RSV within a week or two. But RSV can be serious for certain people who are at high risk, like infants and older adults.

RSV symptoms can take as long as 4 to 6 days to show up after contact with the virus. Symptoms include:

• Runny nose
• Stuffy nose
• Eating less or not interested in eating
• Coughing
• Sneezing
• Red, inflamed eyes (conjunctivitis)
• Fever
• Wheezing (a whistling sound when breathing)
  
  

Symptoms in very young infants may be different. They can include:

• Being irritable or cranky (fussiness)
• Eating or drinking less or not interested in eating
• Decreased activity and poor responsiveness
• Trouble breathing (for example, cough, shortness of breath, wheezing, and respiratory distress)
• Faster breathing than usual
• Pauses in breathing that last more than 10 seconds
  
  

Call your child’s doctor right away if your child is having trouble breathing, not drinking enough fluids, not responding well, and/or their symptoms are getting worse.

What to Do If You Have RSV Symptoms

If you have asthma, contact your doctor right away if you have symptoms of RSV. Or if your infant has RSV symptoms – whether they have asthma or not – contact their doctor.

Most RSV infections will go away on their own. RSV is caused by a virus, so antibiotics will not help. Talk with your doctor about taking over-the-counter medicines to help with symptoms, like pain relievers or cough and cold medicine. Be sure to talk with your doctor about how to take these medicines appropriately. Ask about nasal suction and lubrication – such as a nasal saline spray, mist, or drops – which may help ease congestion. Drink plenty of fluids and rest. Limit your time around other people to prevent spreading RSV.

Cold Symptoms

The common cold is usually mild compared to the flu and COVID-19. But even a mild cold can trigger asthma symptoms, so if you catch a cold, you want to take it seriously.

Common symptoms of a cold include:

• Mild cough
• Sneezing
• Runny or stuffy nose
• Sore throat
• A short fever
• Aches and pains
  
  

What to Do If You Have Cold and Other Respiratory Symptoms

If you start having trouble breathing when sick with a cold, follow your Asthma Action Plan. Contact your doctor if symptoms do not improve. And get medical help right away for emergency asthma symptoms.

Nasal Allergy (Rhinitis) Symptoms

Irritants and allergens can cause inflammation (swelling) in your nose. This is called rhinitis. When you have symptoms during a certain season of the year or when you are exposed to certain allergens, it’s commonly called allergic rhinitis or “hay fever.”

Common allergens that can cause rhinitis include animal dander, dust mites, mold, and pollen.

Allergy symptoms can include:

• Itching in the nose and eyes
• Sneezing
• Stuffy nose (congestion)
• Runny nose
• Mucus (phlegm) in the throat (postnasal drip)
  
  

The inflammation (swelling and irritation) in your nose can cause it to produce a fluid called mucus. The mucus may flow out of your nose, as well as down the back of your throat. It can irritate the back of your throat and cause coughing.

Allergies are not contagious, unlike colds, the flu, and COVID-19. They are caused by a reaction of your immune system.

What to Do If You Have Allergy Symptoms

If you have allergies, the best way to prevent or reduce symptoms is to reduce or avoid contact with the things you are allergic to. Some steps you can take include:

For dust mite allergy:

• Use CERTIFIED asthma & allergy friendly® dust mite-proof covers for pillows, comforters, duvets, mattresses, and box springs.
• Wash your bedding and pillowcases in hot water weekly to reduce allergens.
  
  

For animal dander allergy:

• Keep pets out of the bedroom to reduce pet dander allergen in your bedding.
  
  

For mold allergy:

• Run a fan in your bathroom for 15 to 20 minutes after showering or bathing.
• Fix plumbing leaks in your home as soon as possible.
  
  

For pollen allergy:

• Plan indoor activities on days when pollen counts are high.
• Keep your windows closed during high pollen and mold seasons, if possible. When entering your home, leave your shoes at the door.
• Wear sunglasses, a hat, and a face mask to protect pollen from getting in your eyes, nose, and mouth when outdoors on high pollen days.
  
  

In general:

• Replace the filters on your heating/air conditioning units as recommended by the manufacturer.
  
  

If reducing your exposure to allergens isn’t enough, there are several treatments that can help. Treatments can include nasal sprays, antihistamines, decongestants, and immunotherapy (allergy shots). See a board-certified allergist for allergy testing. They can recommend a treatment plan to help you get relief.

Uncontrolled rhinitis can lead to sinusitis, a sinus infection. If you have asthma, rhinitis symptoms can irritate your lungs and cause asthma symptoms. If you have allergies, it’s important to get treatment to make sure they are well-controlled.

How to Reduce the Spread of COVID-19, the Flu, and Other Respiratory Illnesses

What can you do to reduce your chances of getting sick? To stop the spread of respiratory infections:

• Get vaccinated
• Wash hands often for at least 20 seconds with soap and water
• Wear an N95 face mask when respiratory infections are high in your community
• Increase air flow in your indoor environment

If you have asthma, keeping your asthma under control can reduce your chances of having a severe asthma episode or attack if you get sick.

If you do get sick, get plenty of rest, drink water, and follow your Asthma Action Plan if you have asthma.

Always contact your doctor about any concerning symptoms, no matter what. And go to the emergency department or call 911 for emergency signs and symptoms.

Medical Review: based on the following webpages: COVID-19 (Coronavirus Disease), Asthma, and Allergies reviewed September 2024 by Neeta Ogden, MD; Flu (Influenza) reviewed September 2024 by John James, MD; Respiratory Syncytial Virus (RSV) October 2024 by John James, MD; and Nasal Allergies (Rhinitis)

COVID-19 is a disease caused by a virus called SARS-CoV-2 (a type of coronavirus). It causes respiratory symptoms, but it can also affect other parts of your body.

COVID-19 spreads through close contact from person to person. A person with the virus can spread it to others by talking, coughing, sneezing, singing, or breathing. The virus will be in large or small droplets that are exhaled from the mouth or nose out into the air.

If you are within 6 feet (2 meters) of someone who is ill with COVID-19, you may be at greatest risk for becoming infected. But it may be possible to catch the virus even if you are more than 6 feet away from an infected person because very small droplets can spread in the air. If someone who is sick coughs on or near your face, you may get infected. People may be infected with the coronavirus and not show any symptoms. They may spread the virus without knowing it. The virus may also spread through direct contact with a person who has COVID-19.

What Are the Symptoms of COVID-19?

According to the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO), COVID-19 symptoms can include:

• Fever
• Chills
• Cough
• Shortness of breath or trouble breathing
• Feeling tired and weak
• Muscle or body aches
• Headache
• New loss of taste or smell
• Sore throat
• Stuffy or runny nose
• Nausea or vomiting
• Diarrhea
  
  

If you or someone you know has these emergency warning signs, call 911 or go to the emergency room immediately:

• Trouble breathing or shortness of breath
• Pain or pressure in the chest that doesn’t go away
• Newly confused
• Can’t wake up or stay awake
• Cyanosis which is tissue color changes on mucus membranes (like tongue, lips, and around the eyes) and fingertips or nail beds – the color appears grayish or whitish on darker skin tones and bluish on lighter skin tones
  
  

According to the CDC, this list may not include all symptoms. If you have any symptoms that are severe or concerning, call your doctor.

The CDC warns that symptoms may appear two to 14 days after coming in contact with the virus.

How Can I Tell the Difference Between Asthma, COVID-19, the Flu, a Cold, or Seasonal Allergies?

Some symptoms are similar between these respiratory illnesses. Respiratory illnesses may worsen asthma, so it’s important to keep taking your asthma medicines. If you have a fever and a cough, call your doctor. If you have seasonal allergies, there are things you can do to treat them at home. If your allergy symptoms are hard to control, make an appointment with an allergist.

This chart can help you figure out if you may be feeling symptoms of asthma, allergies, or a respiratory illness like COVID-19, the flu, respiratory syncytial virus (RSV), or a cold:

Click to see larger image (English)

Click to see larger image (Spanish)

Are People With Asthma at Risk of Severe Illness From COVID-19?

Many studies show that having asthma does not put you at a greater risk of getting COVID-19 or having severe COVID-19.^1,2,3 A study published in “The Journal of Allergy and Clinical Immunology: In Practice” (JACI: In Practice) found that people with well-controlled asthma have less severe COVID-19 outcomes than people with uncontrolled asthma.⁴

The CDC continues to list moderate to severe asthma as a chronic lung disease that can make you more likely to have severe illness from COVID-19.

No matter what, it is important to keep your asthma well-controlled. If your asthma is not under control, you are at a greater risk in general of having an asthma episode or attack, going to the emergency room, staying in the hospital, or even death. If you feel like your asthma is not well-controlled, talk with your doctor as soon as possible.

Even though people with asthma are not at the highest risk for COVID-19, it is still important to keep your asthma under control. Common medicines you may take for asthma and allergies do not increase your risk of getting COVID-19. They will help you keep your asthma under control. You are at greater risk for having an asthma attack if you stop taking your medicines. Take your medicines at the first sign of symptoms as listed on your Asthma Action Plan. Continue to take these medicines as prescribed:

• Quick-relief medicine (such as albuterol)
• Inhaled corticosteroids (controller medicines)
• Oral corticosteroids (such as prednisone)
• Biologics
• Antihistamines (allergy medicine)
• Proton pump inhibitors for acid reflux
• Nasal allergy sprays
• Allergy shots
  
  

If you have any questions about asthma medicines and COVID-19, talk with your doctor.

If you need to take quick-relief medicine (such as albuterol) for an asthma episode, use an inhaler (with a spacer if directed by your doctor) if possible. Using a nebulizer can increase the risk of sending virus particles in the air if you are sick. But if you have a nebulizer and solution, it is OK to use it to treat an asthma episode. When using a nebulizer, limit the number of people in the room or use it in a room by yourself.

How Can I Avoid Getting COVID-19 (And Other Respiratory Infections)?

The following steps will help you avoid COVID-19, the flu, and other respiratory infections:

1. Get your vaccines.

Vaccines can help protect you, your loved ones, older adults near you, teachers, and essential workers from getting a respiratory infection. They can also cut down your symptom severity if you do get sick. Vaccines reduce the burden on our health care system by reducing the number of people who get COVID-19 or the flu.

Everyone who is 6 months and older can get a COVID-19 vaccine in the United States. There vaccines available are: Pfizer, Moderna, and Novavax.

Visit vaccines.gov to find out where you can get the COVID-19 vaccine near you. Most people can get the COVID-19 vaccine with no issues. Allergic and adverse reactions are rare.

The flu vaccine is recommended for everyone age 6 months and older with rare exceptions.

It is safe to get both the COVID-19 vaccine and the flu vaccine at the same time.

2. Wear a mask.

Face masks can help reduce the spread of the coronavirus. They can benefit people who are vaccinated and unvaccinated alike. Some people may have COVID-19 and not show symptoms for a few days, while some may not have any symptoms at all. And some vaccinated people have gotten breakthrough infections, which have usually been mild.

Wear a mask that fits snugly on your face, and covers your nose, mouth, and beard completely. Wear a mask when you leave your home, if you are caring for someone at home who is sick, and if you have been exposed to someone with COVID-19. People with asthma should be able to wear face masks.

Face masks offer other benefits as well. They can reduce your exposure to pollen, air pollution, and other respiratory infections like the flu.

3. Keep a physical distance from people outside your household.

In general, the more closely you interact with other people and the longer that interaction, the higher the risk of coronavirus or flu spread. Try to stay home when possible when these illnesses are spreading in your community. Avoid large crowds of people, especially in indoor locations. When in public, keep at least 6 feet apart. Stay away from people who are sick or have been in contact with someone who is sick. Even when you’re at home with family, don’t share makeup, food, dishes, or eating utensils.

4. Wash your hands properly and often.

Use soap and warm water to wash your hands for 20 to 30 seconds. Always wash your hands before and after eating and after coughing or sneezing. Don’t touch your eyes, nose, or mouth.

If you don’t have access to running water, use an alcohol-based hand sanitizer that is at least 60% ethyl alcohol (ethanol) or 70% isopropyl alcohol (isopropanol).

5. Make sure your indoor spaces are well-ventilated and have good indoor air quality.

If you are staying indoors more because of COVID-19, be mindful of the quality of your indoor air. The air inside our homes can often be more polluted than the air outside. Unhealthy indoor air can be full of asthma triggers and allergens that can cause symptoms and make your asthma harder to control. Take steps to improve and maintain healthy indoor air quality.

Air circulation is important too. Keep your indoor spaces well-ventilated by opening windows or doors, using fans, running air cleaners, or using proper air filters in your HVAC system.

Current evidence shows the risk of the coronavirus spreading is much lower outdoors than indoors. Good ventilation in your indoor environment may help reduce the spread of the coronavirus. It may also affect the risk of transmission (how fast it spreads).

On days when pollen is low and air quality is good, open your windows to let in fresh air. Run your HVAC system as much as possible (especially when windows are closed). Use high efficiency air filters in your HVAC system and replace them at least every three months.

6. Take care of your health.

Take your asthma control medicines as directed to keep your airways open. Eat well and get enough sleep.

Pollen (such as grass or ragweed pollen) may impact people across the U.S. too. Seasonal allergies can affect people with allergic asthma. If pollen allergies trigger asthma symptoms for you, be sure to follow your allergy treatment plan to keep your allergies under control to prevent asthma episodes or attacks.

If you stopped seeing your allergist or getting allergy shots (immunotherapy) during the COVID-19 pandemic, consider making an appointment soon. Keeping up with your regular allergist visits is an important part of keeping your asthma controlled.

The most important thing you can do is to keep your asthma under control. If your asthma is not under control, call your doctor right away.

In general, tracking your symptoms and following your Asthma Action Plan are key to managing your asthma. Some people use peak flow meters to monitor their airways. Monitoring your blood oxygen levels with a pulse oximeter (or “pulse ox”) is not a recommended part of home management of asthma. Many pulse oximeters you can buy for home use are not as accurate as medical grade devices.

It is important to remember that the symptoms you feel should always come before pulse ox and peak flow numbers. But if your peak flow numbers are down and you don’t have symptoms, follow your asthma action plan and contact your doctor.

There are no data demonstrating that monitoring your pulse ox through an oximeter or smartphone app will help manage your asthma. As always, talk with your doctor about the best ways to monitor your symptoms and asthma control.⁶

If I Think I Have COVID-19, What Should I Do?

If you start having symptoms of COVID-19, get tested or take an at-home test. If you have mild symptoms and are not at high risk for having more severe COVID-19, you do not need to call your doctor. Call your local health department within 24 hours to let them know so they accurately report local cases.

If you are at high risk for severe COVID-19, call your doctor within 24 hours if you test positive. They may want to you to take the medicine Paxlovid.

Many pharmacies have various testing options (including at-home or drive-thru tests). At times, free tests are available from covidtests.gov.

Some doctors may offer telehealth (video or virtual appointments). If that is an option, ask your insurance company if telehealth is covered under your plan. And if you have Medicare, you might be able to have a virtual visit with your doctor. The government expanded the coverage of telehealth services during the COVID-19 pandemic.

Stay home and isolate from family members so you don’t spread the coronavirus to other people.

Medical Review, July 2022 by Mitchell Grayson, MD; updated November 2024

References
1. Chhiba, K.D., Patel, G.B., Vu, T.H.T, Chen, M.M., Guo, A., Kudlaty, E., Mai, Q., Yeh, C., Muhammad, L.N., Harris, K.E., Bochner, B.S., Grammar, L.C., Greenberger, P.A., Kalhan, R., Kuang, F.L., Saltoun, C.A., Schleimer, R.P., Stevens, W.W., & Peters, A.T. (2020). Prevalence and characterization of asthma in hospitalized and non-hospitalized patients with COVID-19, Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2020.06.010.
2. Butler, M. W., O’Reilly, A., Dunican, E. M., Mallon, P., Feeney, E. R., Keane, M. P., & McCarthy, C. (2020). Prevalence of comorbid asthma in COVID-19 patients. Journal of Allergy and Clinical Immunology. https://doi.org/10.1016/j.jaci.2020.04.061
3. Lieberman-Cribbin, W., Rapp, J., Alpert, N., Tuminello, S., & Taioli, E. (2020). The Impact of Asthma on Mortality in Patients With COVID-19. Chest. https://doi.org/10.1016/j.chest.2020.0air pol.575
4. Huang, B. Z., Chen, Z., Sidell, M. A., Eckel, S. P., Martinez, M. P., Lurmann, F., Thomas, D. C., Gilliland, F. D., & Xiang, A. H. (2021). Asthma disease Status, COPD, and COVID-19 severity in a large Multiethnic POPULATION. The Journal of Allergy and Clinical Immunology: In Practice. https://doi.org/10.1016/j.jaip.2021.07.030
5. Kampf, G., Todt, D., Pfaender, S., & Steinmann, E. (2020). Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. Journal of Hospital Infection, 104(3), 246–251. doi: 10.1016/j.jhin.2020.01.022
6. Heneghan, C. (2018, January 30). Self-management of asthma – is there an app or pulse oximeter for that? Retrieved from https://blogs.bmj.com/bmjebmsp...-app-pulse-oximeter/

Join us for a free, on-demand webinar on how and why nasal polyps impact sense of smell.

Smell and Nasal Polyps: Your Questions Answered

WATCH ON DEMAND

During the webinar, you’ll learn about:

• How loss of smell affects quality of life, mood, appetite, and safety
• The link between loss of smell and nasal-polyp severity
• Treatment options for nasal polyps
• If the loss of smell could better with treatment
• If treatments for nasal polyps improve sense of smell
• How different treatments like biologics and surgery help restore smell
  
  

Don’t miss this chance to take control of your health. Watch now and learn more!

Welcome to our November research update! Getting involved with research is an important way to impact asthma and allergy treatments, education, and awareness.

This month, we are highlighting clinical trials, surveys, and news on:

• Potential asthma treatments
• The impact of environment on asthma
• Moderate to severe eczema in children
• Differences in COVID-19 outcomes based on asthma type
• Study on tezepelumab for nasal polyps
• Impact of corticosteroid use in people with nasal polyps
  
  

Note: The links below will take you to external websites.

Surveys

Community Asthma Survey

If you are over 18 and have asthma, we want to hear about how the environment affects your breathing. By telling your story, you can help others understand and manage asthma better!

The Asthma and Allergy Foundation of America (AAFA) is a partner in this research and appreciates your support!

TAKE THE SURVEY

Participants Needed for Eczema Study

If you are a caregiver for a child under 18 with moderate to severe eczema, we would love to hear your opinions and perspectives. Your feedback can help impact guidelines for childhood eczema. Your child can take the survey too with your help.

Take a 15-minute online survey for a research study on using systemic (oral or injectable) medicines for eczema.

Your voice makes a difference! Each participant will be entered into a drawing for a reward.

Principal Investigator: Dr. Joy Wan (Johns Hopkins Medicine IRB00397225)

TAKE THE SURVEY

Chronic rhinosinusitis is a common medical condition that affects 5-12% of adults.¹ Around 20 to 30% of people with chronic rhinosinusitis have nasal polyps.^2,3 Nasal polyps associated with type 2 inflammation, which is also linked to asthma, allergic rhinitis (hay fever), atopic dermatitis (eczema), food allergies, eosinophilic esophagitis (EoE).⁴

Nasal polyps can have a major impact on quality of life. They can affect sleep, the ability to do daily activities, and cause anxiety and depression. They can also cause safety concerns because they can affect a person’s ability to smell.

The Asthma and Allergy Foundation of America (AAFA) studied the impacts of living with nasal polyps in a report titled, Life with Nasal Polyps: The Patient Experience and Opportunities to Improve Care in the U.S.

As part of our research, we interviewed people with nasal polyps to understand the patient experience. Below, you’ll hear from Tom, Norah, Teresa, Leo, Tamara, and Georgia* about how their experiences line up with some of the key findings of our report.

Diagnosis Can Take a Long Time

For many people, it can take months, or even years, to get a nasal polyps diagnosis. Tom, who was recently diagnosed with nasal polyps, described having symptoms for months before diagnosis.

“For some months I had some nasal congestion issues,” Tom said. “And I really wasn't too happy with the doctor's response. I ended up in the hospital [and] had an ENT say I had a head full of polyps.”

For some people, getting a formal diagnosis can take years. Georgia was diagnosed with nasal polyps after having symptoms and seeing multiple health care providers for years with no relief.

“Before my diagnosis I just had issues with allergies,” recalled Georgia. “Every season it started out with me having sinus infections real bad. So once I started getting sinus infections and I knew it was seasonal, I went to an allergist. From the allergist, I started taking allergy shots. I did that for about a year, and I felt like my allergies weren't getting any better. So then I started having issues with asthma … then it got to the point where I was going back and forth to the hospital, to the ER. Then I decided from there to go to an ENT [who diagnosed me with nasal polyps].”

Nasal Polyps Can Impact Quality of Life

Nasal polyps can have physical impacts like congestion, stuffy and runny nose, and loss of taste or smell. They can also impact mental, social, and emotional health. Teresa, who has had chronic sinus infections as a result of her nasal polyps, described the impact on social life and relationships.

“It impacts your life,” Teresa said. “You have to change plans with friends if you have a sinus infection, and they get worse and worse. You’re constantly altering your life, family events, [you] just lose your energy, and they get harder to fight.”

Leo, a college student, also detailed the impact on school and physical activities.

“I swam before,” Leo said. “I can't really do that anymore just because water goes up in [my nose] and doesn't come back out. It doesn't drain. And so I end up with a sinus infection … There have definitely been times where I’m at work or I’m in class, and I can feel a bad one coming on that I have to just buckle down and know that I’m going to go take a nap or something after.”

The impacts on smell and taste can also be dangerous in some cases. Georgia described times when she couldn’t smell spoiled food or burning in the kitchen.

“I would eat foods and not know if they were spoiled or not,” Georgia said. Like milk, you don't know it's not good, especially if you can't taste or smell it. I could even remember a point where I was in my room, I had put on dinner. And I was sitting on my bed and the alarms went off in the house, and all of a sudden I started seeing white smoke…and then I noticed my throat was feeling a little funny, because I was inhaling the smoke, but I couldn't even taste it or smell it.”

Access to Effective Treatments for Nasal Polyps Can Be Challenging

Nasal polyps can be treated with medicines and surgery. For many of the people we interviewed, getting access to these treatments was a challenge.

Norah, who has managed her nasal polyps well through budesonide nasal sprays, talked about the challenges of getting insurance to approve her prescription.

“The cost is going up,” said Norah. “I'm in the middle of a fight with Medicare. They denied me once, but you can appeal. So, I'm in the middle of an appeal process to get the tier lowered on that drug … And so now I have to ask [my asthma specialist’s] office to reapply. Otherwise, I’m looking at between $80 and $120 a month just for the budesonide because it's a tier 4 drug under Medicare. They denied it because the FDA doesn't see the need for using it that way.”

Tom, who qualified for a biologic treatment for nasal polyps, described the difficult process to get the treatment.

“Getting that prescription was an incredible odyssey all in itself,” said Tom. “Getting it approved or not approved and getting the specialty pharmacy to deliver it … And I'd have to call them every couple of weeks to go through this whole rigamarole all over again. It was not fun.”

Challenges with accessing treatments (especially newer, more expensive options) can be different for everyone. Factors like your insurance provider and plan can play a big role in accessing treatment.

Some people we interviewed also had trouble getting information about surgery.

“I wasn't offered surgery, surgery was never an option,” said Tamara. “I go to my ear nose and throat doctor, [and they say] 'Okay, you look good, you're doing okay.' Surgery was never on the table.”

For others who had surgery to remove their nasal polyps, they often had to try medicines first or do surgeries more than once. And for some people, recovery after surgery can be challenging.

Leo described his experience with surgery: “I got surgery because the drugs didn't work. And the surgery recovery, at least for a couple of [the surgeries], was a pain... two to three weeks of a lot of bleeding and junk coming out, just because of the large amount of stuff that was in there that they had to remove.”

Nasal Polyps Can Impact Quality of Life

Nasal polyps can have physical impacts like congestion, stuffy and runny nose, and loss of taste or smell. They can also impact mental, social, and emotional health. Teresa, who has had chronic sinus infections as a result of her nasal polyps, described the impact on social life and relationships.

“It impacts your life,” Teresa said. “You have to change plans with friends if you have a sinus infection, and they get worse and worse. You’re constantly altering your life, family events, [you] just lose your energy, and they get harder to fight.”

Leo, a college student, also detailed the impact on school and physical activities.

“I swam before,” Leo said. “I can't really do that anymore just because water goes up in [my nose] and doesn't come back out. It doesn't drain. And so I end up with a sinus infection … There have definitely been times where I’m at work or I’m in class, and I can feel a bad one coming on that I have to just buckle down and know that I’m going to go take a nap or something after.”

The Need for More Nasal Polyps Support and Resources

Our report highlighted a need for more support and resources for nasal polyps. Tamara, who was diagnosed at age 14, described frustrations in the education she received from her health care provider when she was first diagnosed.

“Especially when you're talking to a 14-year-old, the big thing is compliance,” said Tamara. “And if you don't explain why compliance is important, at some point, they’re going to get tired of doing things. [They] get tired of using nasal sprays and stop because they don’t understand what can happen if they don’t. And he never bothered to explain all of that. He just said, ‘You need to take it, and it may help your ear problems,’ but that was it. He never went into details.”

As such, she explained how doing her own research as a nurse practitioner helped her learn more about nasal polyps.

“Once I became a nurse, I researched it myself,” Tamara recalls. “Sometimes you have to do your own research and be your own advocate. So that’s pretty much what I did … I was able to understand things to the point where I was better able to ask questions and get the answers that I needed.”

Teresa also talked about how important it is to raise awareness about nasal polyps among health care providers.

“I just wish more local allergists were aware,” Tamara said. “For a time, I was just seeing an allergist and a pulmonologist to treat the allergy and asthma because I had dealt with other allergists, and no one was helping … So I wish there was more training in polyps and awareness of that. I don’t feel like every allergist and every ENT is aware.”

There is also a need for more education and awareness for people with nasal polyps. Norah spoke about the need for more information on day-to-day management.

“I would just love more information. Other than what I’m doing, is there anything I can do to keep these from growing back or keep them under control? I guess it would be just more ways of controlling and keeping them from coming back.”

Georgia also stressed the importance of raising awareness among caregivers and loved ones.

“They’re looking like, ‘Huh? Polyps? I’ve heard of cancerous polyps, but not nasal polyps.’ And then you got to go through the spiel and be the doctor and break down things and give people terminologies and stuff, and they’re still lost.”

The Life with Nasal Polyps report was developed independently by AAFA and made possible by support from Sanofi and Regeneron.

*Names have been changed for privacy.

References
1. Dietz de Loos, D., Lourijsen, E. S., Wildeman, M. A. M., Freling, N. J. M., Wolvers, M. D. J., Reitsma, S., & Fokkens, W. J. (2019). Prevalence of chronic rhinosinusitis in the general population based on sinus radiology and symptomatology. Journal of Allergy and Clinical Immunology, 143(3), 1207–1214. https://doi.org/10.1016/j.jaci.2018.12.986
2. Stevens, W. W., Schleimer, R. P., & Kern, R. C. (2016). Chronic Rhinosinusitis with Nasal Polyps. The Journal of Allergy and Clinical Immunology: In Practice, 4(4), 565–572. https://doi.org/10.1016/j.jaip.2016.04.012
3. Benjamin, M. R., Stevens, W. W., Li, N., Bose, S., Grammer, L. C., Kern, R. C., Tan, B. K., Conley, D. B., Smith, S. S., Welch, K. C., Schleimer, R. P., & Peters, A. T. (2019). Clinical Characteristics of Patients with Chronic Rhinosinusitis without Nasal Polyps in an Academic Setting. The Journal of Allergy and Clinical Immunology: In Practice, 7(3), 1010–1016. https://doi.org/10.1016/j.jaip.2018.10.014
4. Bachert, C., Hicks, A., Gane, S., Peters, A. T., Philippe Gevaert, Nash, S., Horowitz, J. E., Sacks, H., & Jacob-Nara, J. A. (2024). The interleukin-4/interleukin-13 pathway in type 2 inflammation in chronic rhinosinusitis with nasal polyps. Frontiers in Immunology, 15. https://doi.org/10.3389/fimmu.2024.1356298

If you’re on Medicare, a new program will be available in 2025 that might make it easier to pay for your medicines. It’s called the Medicare Prescription Payment Plan.

What Is the Medicare Prescription Payment Plan?

The Medicare Prescription Payment Plan is a program that lets you spread out your estimated out-of-pocket drug costs throughout the year. If you have a Medicare Part D or Medicare Advantage plan, you have the option to sign up for the program starting on Jan. 1, 2025.

The Medicare Prescription Payment Plan is part of the Inflation Reduction Act that passed in 2022. It included several items, including this program, that would help people with asthma and allergies. The Asthma and Allergy Foundation of America (AAFA) supported the Inflation Reduction Act in 2022, and we are happy that this program is now available to help people with asthma who are on Medicare better manage the cost of their medicines.

The Inflation Reduction Act also caps Medicare out-of-pocket drug costs to $2,000 per year. This benefit is for everyone on Medicare, not just people who sign up for the Medicare Prescription Payment Plan.

How Can I Sign Up for the Medicare Prescription Payment Plan?

The program is optional, but it may help you if you pay high drug costs, especially at the beginning of the year.

To sign up, go to the website for your health or drug plan. Or call your plan to set it up:

If you want to participate in the Medicare Prescription Payment Plan in 2025, contact your prescription plan as soon as possible. The plan will start Jan. 1, 2025.

You can also sign up for the plan at any time during 2025. After Jan. 1, 2025, contact your prescription plan to sign up for the Medicare Prescription Payment Plan anytime.

Will the Medicare Prescription Payment Plan Reduce the Cost of My Medicines?

No, the program will not reduce your medicine costs. But it will spread out your costs over the year so you can manage your budget better. The new $2,000 out-of-pocket cap may help reduce your yearly costs if you normally spend more than that on your medicines.

How Can I Save Money on My Prescription Medicines?

Many pharmaceutical companies, state programs and nonprofits have drug assistance programs (PAPs) that offer free or low-cost medicines. AAFA has a list of several drug assistance programs.

Some programs may not offer help to people with Medicare, but you may be able to get help through these options:

• Extra Help from Medicare
• State Pharmaceutical Assistance Program
• Pharmaceutical assistance program for people in a Medicare Part D drug plan
  
  

Each year, usually in the fall, you have the chance to change or sign up for health insurance coverage. Here is a review of what you need to know in order to enroll in a plan, whether you are getting insured for the first time, or are switching plans.

What Are Open Enrollment Terms I Need to Know?

When you review your options for health insurance, there are some terms you need to know so you can make the best decision for you and your family.

A health care provider is a person who is trained and licensed to provide health care, such as a doctor or nurse.

Open enrollment refers to the time period when you can add or change your health insurance. Outside of that time frame, you can only make changes if you have a certain change in your circumstances.

A special enrollment period is a time outside the yearly open enrollment period when you can sign up for health insurance through the marketplace. Certain life events will qualify you for this enrollment period, like getting married, having a baby, adopting a child, moving, or losing health coverage.

Your monthly premium is what you pay each month for the cost of your health insurance plan.

There are also costs you pay each time you need care. These are called out-of-pocket costs.

Out-of-pocket pocket costs include the following:

• A deductible is what you pay each year for health care services or medicines before your insurance begins paying.
  
  
• Copayments are what you pay to see a health care provider. For example, it may cost $15 to see your primary care doctor and a visit to your asthma specialist might cost $30.
  
  
• Coinsurance is the percentage of your your medical expenses you must pay, including medicines, hospital stays, office visits, etc.
  
  
• Covered services means what your health plan will pay for. This includes medical treatments and prescription medicine.
  
  

Finally, know which doctors, specialists and other health care providers are in-network or out-of-network.

• In-network means that your health plan has an agreement with that a group of specific providers for your health care. Copayments and other costs  generally cost less if you use in-network providers.
  
  
• Out-of-network means there is no agreement between the health insurance company and the provider. Your costs will be higher to see a health care provider out of network.
  
  

For more insurance definitions, see this list of common terms.

Where Can I get Health Insurance?

Millions of people in the United States can get health insurance through their jobs. If your employer does not offer health insurance benefits, you have other options.

You can buy insurance through the Health Insurance Marketplace, created by the Affordable Care Act.

Open enrollment for these plans ends on Dec. 15, 2024, for coverage that starts on Jan. 1, 2025. You can apply until Jan. 15, 2025, for coverage that starts Feb. 1, 2025.

If you don’t act by Jan. 15, 2025, you can’t get coverage for 2025 unless you qualify for a special enrollment period. Some states may have a longer open enrollment period.

How Can I Get Help If I Have Questions?

HealthCare.gov has free tools, and many communities offer help to make sure you feel confident you’ve picked the right plan for you and your family. If you have questions about signing up or want to talk through your options with a trained professional, you can get free and confidential assistance:

• Online: Information is available at HealthCare.gov and CuidadoDeSalud.gov.
  
  
• By phone: Marketplace call center representatives are available to help all day, every day at 1-800-318-2596. TTY users should call 1-855-889-4325. Assistance is available in many languages. The call is free.
  
  
• In person: Consumers can find free and confidential local help in their communities by visiting HealthCare.gov or you can make an appointment with the Get Covered America Connector.
  
  

When you apply for insurance, you'll find out if you qualify for financial help to pay your monthly premiums.

_{Updated October 2024}

If you have asthma or allergies, costs for medicines, lab tests, lung function tests, and visits to see a specialist all add up. Health insurance can help with some of these costs. What do you need to know about your insurance options during open enrollment this year?

Open enrollment refers to when you can add, change, or switch health insurance plans. For people who get health insurance through work, your employer and the insurance company set the dates for open enrollment periods.

The Affordable Care Act (ACA) makes health insurance more affordable and available to people without insurance benefits through their employer, Medicare, Medicaid, or another source. It includes other important provisions for people with allergic diseases. For example, if you buy a Marketplace plan, you cannot be denied because you have a pre-existing condition, such as asthma.

How Do I Enroll in a Health Insurance Plan?

If your job offers health insurance benefits, you will need to follow your employer's instructions on how to enroll.

If you do not have health insurance benefits from your employer, or if you are uninsured, you can apply through the Marketplace. You can preview and compare plans before you choose a plan.

Here is a checklist of what information to have on hand to help you make a decision:

• Your household size
• Home and/or mailing address for everyone needing coverage
• Information about everyone needing coverage, like birth dates and Social Security Numbers
• Information about any professional person who is helping you apply (for example, agent or broker)
• Information on how you plan to file your taxes in 2025
• Income information, such as pay stubs and W-2s for every member of your household
• Policy numbers from your current health care plans
• Estimated household income in 2025
• Completed "Employer Coverage Tool" if anyone in your household can get insurance through an employer
• Notices from your current Marketplace plan, if you had one for 2024
• Documents for legal immigrants and naturalized citizens in your household
  
  

HealthCare.gov also has a checklist to help you get ready to apply.

When looking at plans on the Marketplace, you can choose to “estimate total yearly costs.” To do so, you will be asked to select the level of care you expect to use this year. It's OK if you end up using more or less. This won't change your premiums or cost-sharing, or limit how many services you can use.

You might select "Low Use" if you expect:

• Few doctor visits
• Occasional prescription drugs
• No expected hospital visits
  
  

You might select "Medium Use" if you expect:

• Regular doctor visits
• Regular prescription drugs
• No expected hospital visits
  
  

You might select "High Use" if you expect:

• Frequent doctor visits
• Frequent prescription drugs
• At least 1 hospital visit
  
  

What Is Important to Consider If I Have Asthma or Allergies?

1. Are your current health care providers in-network, such as your primary care doctor and your specialists?
2. Does the plan include care from an asthma and allergy specialist?
3. What medicines are covered by the plan? Look for the drug list or formulary.
4. Does the health insurance plan require a referral required to see a specialist? Be aware that the number and type of plans will vary by state. Some states may have a wide choice of plans. Others may offer a health maintenance organization (HMO), which may require you to get a referral to see a specialist.
5. What kind of treatments for asthma or allergies are covered by the plan?
6. Will the plan pay for more advanced treatments, or will it limit the kind of treatment you can receive?
7. Does the plan cover diagnostic tests for diagnosing asthma or allergies, such as lung function tests and skin prick testing?
8. Will the plan cover medical devices such as spacers and nebulizers?
9. Does the plan offer an asthma management program? Under program “details,” you can see if the health insurance plan covers asthma management. Many plans do. Asthma management programs may include a nurse hotline, help identifying your asthma triggers, assistance understanding your medicine, or using equipment like nebulizers and spacers.
   
   

What Are the “Metal” Categories in the Health Insurance Marketplace?

ACA plans fall under the categories of Bronze, Silver, Gold, and Platinum. The levels have nothing to do with quality. They refer to how you and your insurance plan split costs, known as cost-sharing.

Consider Silver if you qualify for extra savings on out-of-pocket costs, or if you want more of your costs covered.

• If you qualify for extra savings (“cost-sharing reductions”), your deductible will be lower, and you’ll pay less each time you get care. These extra savings are only available through the Silver plan. This can save you hundreds or even thousands of dollars a year if you use a lot of care. Silver carries moderate premiums and deductibles.
• While a Silver plan may have a monthly premium that’s higher than a Bronze plan’s premium, be sure to consider the total cost of your medical care. Your total costs include not just monthly premiums but the payments you make when you get care.
• If you have a Silver plan and qualify for extra savings, the deductible can be thousands of dollars less than a typical Bronze plan’s deductible. So, you may end up spending less on health care overall if you enroll in a Silver plan.
  
  

Consider Gold or Platinum if you expect a lot of health care visits or need regular prescriptions.

These plans generally have higher monthly premiums but pay more of your costs when you need care.

What Are Advance Premium Tax Credits?

Advance premium tax credits (APTC) can help lower the cost of your monthly premium. Whether or not you qualify depends on your household size and household income.

When you apply for coverage through HealthCare.gov, you will find out instantly if you qualify for this credit or not. You can also quickly check if you might qualify on their website without an application.

The government may pay your tax credit directly to the insurance company, lowering the cost of the monthly premium that you pay out of pocket. Or you may choose to pay the full premium amount and get a refund at the end of the year.

What If I Have Low Income?

When you apply for coverage, you will also find out if you qualify for:

• Medicaid
• CHIP (the Children’s Health Insurance Program)
  
  

Both provide free or low-cost health coverage for some people, including low-income adults, children, pregnant women, seniors and people with disabilities. Medicaid provides insurance to more than 72 million people in the United States.

These programs may be known by different names in each state. Some states have expanded their Medicaid programs to cover all adults below a certain household income. Learn more about the expansion and what it means to you.

I Have Insurance Through My Job. Should I Look at the Marketplace?

You can, but the Marketplace is intended for people without health insurance. Since the ACA was passed, job-based health insurance must meet certain standards. You will pay full price for a Marketplace plan unless your coverage through work does not meet those standards.

Should I Buy “Catastrophic” Coverage, Short-Term Insurance or Hospital-Only Coverage?

The Catastrophic health plans may look like health insurance, but they do not meet the minimum standard for ACA plans or job-based health plans. For instance, they will not include prescription medicine or preventative care, both of which are important for people with asthma and allergies.

If you are under 30 years old, you can get a Catastrophic health plan without an exemption.

If you are 30 years old or older, you have to apply for a hardship exemption or affordability exemption.

Will I Pay a Penalty If I Don't Buy Health Insurance?

As of 2019, you no longer have to pay a tax penalty if you are uninsured. But you might still be subject to a state tax penalty.

How Can I Get More Help While Applying?

Enter your ZIP code or city and state and get connected to someone who can help you locally.

Where Can I Learn More?

AAFA’s advocacy resources have more details about health care coverage and insurance issues, including Medicaid, Medicare and CHIP.

Updated October 2024

Welcome to our October research update! Getting involved with research is an important way to impact asthma and allergy treatments, education, and awareness.

This month, we are highlighting clinical trials, surveys, and news on:

• New treatment options for eczema, chronic spontaneous urticaria (CSU), chronic obstructive pulmonary disease (COPD), eosinophilic granulomatosis with polyangiitis (EGPA), and nasal polyps
• The impact of climate change and environment on asthma and allergies
• Safety of direct penicillin challenges
  
  

Note: The links below will take you to external websites.

Surveys

Community Asthma Survey

If you are over 18 and have asthma, we want to hear about how the environment affects your breathing. By telling your story, you can help others understand and manage asthma better!

The Asthma and Allergy Foundation of America (AAFA) has a participating member on the survey steering committee and appreciates your support!

TAKE THE SURVEY

Participants Needed for Eczema Study

If you are a caregiver for a child under 18 with moderate to severe eczema, we would love to hear your opinions and perspectives. Your feedback can help impact guidelines for childhood eczema. Your child can take the survey too with your help.

Take a 15-minute online survey for a research study on using systemic (oral or injectable) medicines for eczema.

Your voice makes a difference! Each participant will be entered into a drawing for a reward.

Principal Investigator: Dr. Joy Wan (Johns Hopkins Medicine IRB00397225)

TAKE THE SURVEY

Latest Asthma and Allergy News

Anaphylaxis

neffy® Epinephrine Nasal Spray Now Available in the U.S.
In August 2024, the Food and Drug Administration (FDA) approved the epinephrine nasal spray, neffy®, for adults and children over 66 pounds for the treatment of severe allergic reactions, including anaphylaxis. The treatment is now available by prescription in the United States. Through the neffyConnect program, eligible people with commercial insurance can purchase 2 single-use devices for $25. Uninsured people can buy them for $199. Neffy is also available free to people who qualify for the ARS Patient Assistance Program. The nasal spray offers a needle-free alternative to epinephrine auto-injectors. Experts believe neffy will encourage more people to carry and use their epinephrine earlier during an allergic reaction. This can lead to treatment outcomes and fewer emergency room visits.

Allergy

How Climate Change Impacts Allergies
A recent article examined the impact of increased use of fossil fuels on the environment and allergic conditions. Increased use of fossil fuels has led to global warming, causing more extreme weather events like wildfires and storms. This results in higher levels of air pollutants, including particulate matter, greenhouse gases, and pollen. Together, these factors worsen allergic diseases.

Factors like droughts, floods, heat waves, pollution, and deforestation also add to the rise in allergies. As global warming and extreme weather continue to worsen, allergic diseases are expected to increase, which can put more strain on health care systems.

To improve health, the authors say we need to address climate change by reducing fossil fuel use and promoting biodiversity. Health care providers can also play a key role in educating patients about climate change's effects on health and advocating for policy changes to create a healthier, more sustainable future.

Safety of Direct Penicillin Challenges
In a direct penicillin challenge, a patient is given a small dose of penicillin and is monitored for signs of an allergic reaction. A recent study looked at how often people labeled as allergic to penicillin have allergic reactions during direct penicillin challenges.

The researchers analyzed data from 56 studies involving 9,225 participants. It found that only 3.5% of people experienced a reaction, most of which were mild. Children, outpatients, and people receiving graded or prolonged challenges had higher rates of reaction. Only 5 severe reactions were reported, including 3 cases of anaphylaxis, but none were fatal. These findings suggest that direct penicillin challenges are generally safe and could be widely used to evaluate penicillin allergies, helping reduce unnecessary allergy labels in both children and adults.

Asthma

Risk Factors for Missing Appointments Among Children with Asthma
Missing scheduled asthma appointments has been linked to more asthma flare-ups in children and higher health care costs. This study reviewed 17 studies involving 27,023 children to identify risk factors for missing appointments. It found that teenagers, non-White children, and children with less severe asthma were more likely to miss appointments. The analysis did not find significant differences based on insurance, allergies, gender, or rural living.

The study also showed that children who missed appointments had a higher risk of acute asthma events. These findings highlight the need to develop strategies to reduce missed appointments in children with asthma, which could lower the risk of severe asthma episodes.

A Look at Azithromycin as a Low-Cost Asthma Treatment
New treatments for severe asthma have greatly improved how the condition is managed, leading to better quality of life and fewer asthma attacks. Some treatments aim for “remission,” meaning patients experience no symptoms and do not need steroids. But defining remission is challenging, and it’s unclear what helps people reach this state.

One potential treatment is azithromycin, an antibiotic that may help reduce asthma attacks, especially for people with non-type 2 asthma. A study found that people with asthma taking azithromycin had higher rates of clinical remission compared to people who didn’t take the treatment. While azithromycin is affordable and widely available, it can have side effects and may lead to antibiotic resistance. More research is needed to fully understand its long-term effects and how it works with other asthma treatments.

Atopic Dermatitis (Eczema)     

FDA Approves EBGLYSS™ for People 12 Years and Older with Moderate-to-Severe Atopic Dermatitis
In September, the FDA approved EBGLYSS for moderate to severe atopic dermatitis (AD) in people aged 12 and older who weigh at least 88 pounds and have not found relief with creams. EBGLYSS is an injectable biologic that can be used alone or with topical steroids. EBGLYSS works by blocking a protein that causes excessive inflammation. Treatment begins with two injections at weeks 0 and 2, followed by one every 2 weeks until week 16, after which patients can switch to a monthly dose. In clinical trials with over 1,000 participants, 38% of those on EBGLYSS had clear or almost clear skin by week 16, compared to 12% who did not take the treatment. Also, 43% of participants had itch relief at week 16. Common side effects include redness, swelling, and skin irritation.

Chronic Spontaneous Urticaria (CSU)

Dupixent® Phase 3 Trial Shows Improvements in Itch and Hives for Patients with Chronic Spontaneous Urticaria (CSU)
Chronic spontaneous urticaria (CSU) is a condition that causes sudden hives and intense itching, affecting quality of life. Regeneron Pharmaceuticals and Sanofi have announced that their drug Dupixent® (dupilumab) has successfully completed a Phase 3 trial for treating uncontrolled chronic spontaneous urticaria (CSU) in patients who have not previously used biologics. The trial showed that Dupixent significantly reduced itch and hive activity compared to non-treatment.

In the study, 30% of patients treated with Dupixent reported no urticaria at 24 weeks, compared to 18% who did not take the treatment. The safety of Dupixent was consistent with its known profile, with similar rates of side effects for both groups. The results will be submitted to the U.S. Food and Drug Administration by the end of 2024 to seek approval for CSU treatment.

COPD

FDA Approves Dupixent as the First-Ever Biologic Medicine for Patients with COPD in the U.S.
The FDA has approved Dupixent (dupilumab) as a maintenance treatment for adults with chronic obstructive pulmonary disease (COPD) who have an eosinophilic phenotype. This makes Dupixent the first biologic medicine approved in the U.S. for these patients. COPD can cause severe symptoms like breathlessness, coughing, and fatigue, making daily activities difficult. The approval is based on 2 major studies showing Dupixent significantly reduces severe COPD flare-ups and improves lung function compared to non-treatment. Patients taking Dupixent experienced a 30% to 34% decrease in annual flare-ups and better quality of life scores. Common side effects included viral infections, headaches, and back pain. This approval offers new hope for better managing COPD symptoms and improving patients’ lives.

EGPA

FDA Approves FASENRA for Eosinophilic Granulomatosis with Polyangiitis (EGPA) in the U.S.
AstraZeneca’s FASENRA® (benralizumab) has been approved in the U.S. to treat adults with eosinophilic granulomatosis with polyangiitis (EGPA), a rare and serious condition that can harm multiple organs. The approval followed the MANDARA Phase III trial, which compared FASENRA with the only other approved EGPA treatment, mepolizumab. In this trial, nearly 60% of patients treated with FASENRA achieved remission, similar to those on mepolizumab. Also, 41% of FASENRA patients could stop using oral corticosteroids, compared to 26% of those taking mepolizumab. This new treatment offers a convenient monthly injection and may help patients reduce reliance on long-term steroids, which can have severe side effects. FASENRA is also approved for severe eosinophilic asthma in over 80 countries.

Nasal Polyps

FDA Approves Dupixent® as First and Only Treatment for Adolescents with Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) in the U.S.
Approximately 9,000 adolescents in the U.S. have chronic rhinosinusitis with nasal polyps (CRSwNP). CRSwNP is a long-term condition that blocks nasal passages, causing breathing issues and affecting the sense of smell and taste. Regeneron Pharmaceuticals and Sanofi recently announced that the U.S. FDA has approved Dupixent (dupilumab) as a treatment for adolescents aged 12 to 17 with CRSwNP that isn't well controlled. This approval expands Dupixent's use, which was initially approved in 2019 for adults with CRSwNP. The approval is based on two clinical trials that showed Dupixent significantly reduced nasal congestion and polyp size while decreasing the need for surgery or steroids. Dupixent has a proven safety record, with common side effects like injection site reactions and insomnia. This new approval provides adolescents with a treatment option beyond current standard therapies.

Eczema is a group of chronic skin conditions that cause your skin to become inflamed, dry, itchy, and irritated. The rash can be a different color than your normal skin tone. Atopic dermatitis (AD) is the most common type of eczema. If you or a family member has asthma and allergies, you have a higher chance of having AD. It affects nearly 10 million children and 17 million adults in the United States.

Living with AD can be challenging. Many people living with AD report symptoms like sore and painful skin, and poor sleep caused by itching. These physical symptoms can also impact mental health, social life, and overall well-being.

There is no cure for AD., but it can be managed through medical treatments like topical corticosteroids, non-steroidal topicals, and biologic treatments. AD can also be managed by avoiding known triggers and managing stress.

In 2024, the Food and Drug Administration (FDA) approved 2 new treatments for AD:

1. ZORYVE® (a non-steroidal treatment that you put on your skin)
2. EBGLYSS™ (a biologic)
   
   

Here is more information about these new treatments, how they work, and the research that supports their approval:

ZORYVE®

In July, the FDA approved ZORYVE cream for the treatment of AD in children and adults aged 6 and older. ZORYVE is a once-daily, steroid-free topical cream. It can be used on any location on the body affected by AD and can be used for as long as needed.

ZORYVE was previously approved for the treatment of seborrheic dermatitis and plaque psoriasis. ZORYVE works by blocking an enzyme called PDE4. Blocking this enzyme can help calm down the body’s nerves on the skin that cause you to itch and reduce inflammation caused by conditions like AD.  

The approval of ZORYVE cream is based on positive results from several studies. In these studies, people with mild to moderate AD used ZORYVE cream or a placebo cream for 4 weeks.

The studies showed that ZORYVE helped many patients improve their skin. About 40% of people had clear or almost clear skin by the end of the 4 weeks.

The cream also helped reduce itching quickly. Some people felt better within 24 hours. More than 30% of participants had major itch relief after 4 weeks. Long-term studies also showed that many participants continued to improve. More than 60% had significant relief up to 56 weeks.

Very few participants reported adverse reactions. Most of the people who did report  side effects said they had headaches, nausea, and minor skin irritation where they used treatment.

EBGLYSS™

In September, the FDA approved EBGLYSS for the treatment of moderate to severe AD in people aged 12 and older who weigh at least 88 pounds and who have AD that is not well-controlled with creams or ointments.

EBGLYSS is an injectable biologic treatment that can be used alone or with topical steroids. EBGLYSS works by blocking a protein in the body that causes too much inflammation.

Treatment starts with 2 injections at week 0 and week 2, followed by 1 injection every 2 weeks until week 16. After that, you can switch to a monthly maintenance dose.

The FDA approved EBGLYSS based on findings from 3 clinical trials that included more 1,000 people. In these studies, 38% of people who took EBGLYSS had clear or almost clear skin at week 16, compared to 12% of participants who did not receive treatment. One in 10 participants who took EBGLYSS saw these results in as early as 4 weeks. Of the people who experienced clear or almost-clear skin at week 16, most (77%) maintained those results at 1 year with monthly maintenance dosing.

Many participants also had itch relief with EBGLYSS. On average, 43% of people who took EBGLYSS felt itch relief at week 16, compared to 12% of participants who did not get the treatment. Of the people who felt itch relief at week 16, most (85%) still felt relief at 1 year of treatment with monthly maintenance dosing.

The most common side effects of EBGLYSS include redness, swelling, and inflammation of the eye and eyelid, minor skin irritation at the injection site, and shingles.

The recent FDA approvals of EBGLYSS and ZORYVE provide more treatment options for people living with eczema. Both treatments offer new ways to manage challenging symptoms like itching and irritation. With more treatment options available, people with AD are one step closer to getting relief and improving their quality of life. As always, talk with your health care provider to see if one of these treatments might be right for you.